Association Between Serum Levels of Anti-heat Shock Protein 27 Antibody and Liver Cell Injury in Chronic Hepatitis B

Heat Shock Protein 27 (HSP27), an anti-HBV factor, exists in the intracellular and extracellular spaces. As inflammatory modulator, serum HSP27 (sHSP27) is associated with elevated pro-inflammatory cytokines a higher likelihood of hepatocellular carcinoma chronic hepatitis. SHSP27 results natural antibody production (anti-HSP27-Ab) that more stable easily detectable compared to sHSP27. We aimed investigate any potential association between anti-HSP27-Ab level hepatitis B (CHB) progression inflammation indicated by liver cell injury HBV replication. This cross-sectional study was conducted on 91 patients CHB 92 individuals without CHB. Following demographic data collection, anti-HSP27-Ab, lipids including total cholesterol, triglyceride, LDL-C, HDL-C, aminotransferase levels were measured using enzymatic assays participants’ samples. DNA also quantitative PCR patients. Bivariate multivariate analyses showed significantly mean than healthy (0.304 vs. 0.256AU/ml, P value = 0.015). These held significant differences subgroups male patients, at age 50 years above, non-smoking status, levels, hypotriglyceridemia (P < 0.05). However, no difference found copies > provides evidence anti-HSP27 can reflect degree necrosis levels. Regarding incidence rate HBV-associated complications 60-year-old men, monitoring be beneficial managing this group which deserves further investigation.